Histological, Laboratorial, and Clinical Benefits of an Optimized Maintenance Strategy of a Potential Organ Donor—A Rabbit Experimental Model

Introduction: Most transplanted organs are obtained from brain-dead donors. Inflammation results in a higher rate of rejection. Objectives: The objective this animal model brain death (BD) was to evaluate the effect progressive institution volume expansion, norepinephrine, and combined hormone therapy on clinical, laboratory, histological aspects. Methods: Twenty rabbits were divided: A (control), B (induction BD + infusion crystalloid), C (BD crystalloid noradrenaline (NA)), D vasopressin levothyroxine methylprednisolone NA). animals monitored for four hours with consecutives analysis vital signs blood samples. evaluated by pathologist. Results: In Group D, we observed fewer number lesser infusions (p = 0.032/0.014) when compared groups C. Mean arterial pressure levels group 0.008). had better glycemic control 0.016). Sodium values elevated relation 0.021). organ perfusion better. Conclusion: optimized strategy management is associated hemodynamic, glycemic, natremia control, besides reducing early ischemia.